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目的探讨新辅助化疗疗效与Caspase-7、Caspase-3、Survivin的关系。方法用免疫组织化学法检测46例乳腺癌新辅助化疗前后石蜡包埋福尔马林固定标本Caspase-7、Caspase-3、Survivin的表达变化。结果新辅助化疗有效率为80.43%。Caspase-7新辅助化疗前后阳性率分别为67.39%、86.96%,P<0.05;Caspase-3分别为63.04%、84.78%,P<0.05;Survivin分别为71.74%、47.83%,P<0.05。化疗前Caspase-7与Caspase-3阳性者化疗疗效好于阴性者(P均<0.05)。结论Caspase-7、Caspase-3、Survivin的表达变化与新辅助化疗疗效密切相关。
Objective To investigate the relationship between neoadjuvant chemotherapy and Caspase-7, Caspase-3 and Survivin. Methods The expressions of Caspase-7, Caspase-3 and Survivin in paraffin-embedded formalin fixed specimens of 46 cases of breast cancer before and after neoadjuvant chemotherapy were detected by immunohistochemistry. Results The neoadjuvant chemotherapy efficiency was 80.43%. The positive rates of Caspase-7 before and after neoadjuvant chemotherapy were 67.39% and 86.96% respectively, P <0.05; Caspase-3 was 63.04% and 84.78% respectively, P <0.05; Survivin was 71.74% and 47.83%, respectively; Chemotherapy before Caspase-7 and Caspase-3 positive chemotherapy is better than negative (P all <0.05). Conclusion The expressions of Caspase-7, Caspase-3 and Survivin are closely related to the efficacy of neoadjuvant chemotherapy.