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为揭示白虎追风胶囊的抗炎作用机理 ,研究了白虎追风胶囊对佐剂性关节炎 (AA)大鼠滑膜白细胞介素 - 1(IL - 1)、肿瘤坏死因子α (TNF -α)和前列腺素E2 (PGE2 )的影响 ,以及对AA大鼠血液中氧自由基和NO的影响。结果显示 :白虎追风胶囊能下调AA大鼠滑膜过度分泌的IL - 1、TNF -α和PGE2 ;能降低AA大鼠过高的LPO和NO水平 ,使过低的SOD和GSH -Px增高。提示白虎追风胶囊的作用机制可能与其抑制滑膜分泌细胞因子和炎症介质 ,以及抗氧化作用有关。
In order to reveal the mechanism of anti-inflammation effect of Baihu Chafeng Capsule, the synergistic effect of Baihu Chafeng Capsule on interleukin-1 (IL-1) and tumor necrosis factor α (TNF-α) in synovial membrane of adjuvant arthritis (AA) rats was studied. ) and the effects of prostaglandin E2 (PGE2), as well as the effect of oxygen free radicals and NO in the blood of AA rats. The results showed that Baihu Houfeng capsule can reduce IL-1, TNF-α and PGE2 secreted by synoviocytes of AA rats; it can reduce the excessive LPO and NO levels in AA rats and increase the over-low SOD and GSH-Px levels. . It is suggested that the mechanism of action of Baihu Chafeng Capsule may be related to its inhibition of secretion of cytokines and inflammatory mediators by synovial membranes, as well as antioxidation.