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目的探讨血清C-反应蛋白在下呼吸道感染患者中的临床价值。方法选择61例下呼吸道感染患者,分别在治疗前后予以检测血清C-反应蛋白(CRP),血沉(ESR)及血白细胞(WBC),进行对比分析。结果 CRP敏感度为98.36%,WBC+ESR综合指标判断敏感度为34.43%,两种指标判断经χ2检验差异有统计学意义(χ2=37.03,P<0.01),即下呼吸道感染治疗前采用CRP指标判断下呼吸道感染的敏感度高于WBC+ESR综合指标判断。治疗后CRP敏感度为49.18%,WBC+ESR综合指标判断敏感度为0.33%,两种指标判断经χ2检验,差异有统计学意义(χ2=26.04,P<0.01),即下呼吸道感染治疗后采用CRP指标判断下呼吸道感染的敏感度仍高于WBC+ESR综合指标判断。结论 CRP水平与结合患者的症状和体征,可以指导下呼吸道感染的治疗。C-反应蛋白对下呼吸道感染患者的判断及疗效较血常规及ESR敏感有效,可作为观察疗效和判断预后的指标,避免抗生素过早停用贻误病情,同样也增加了有效避免抗生素过度使用产生耐药性的方法。可指导抗菌药物的合理使用和管理。
Objective To investigate the clinical value of serum C-reactive protein in patients with lower respiratory tract infection. Methods Sixty-one patients with lower respiratory tract infection were selected. Serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and white blood cell (WBC) were measured before and after treatment. Results The sensitivity of the CRP was 98.36% and the sensitivity of the WBC + ESR composite index was 34.43%. The difference between the two indexes was statistically significant (χ2 = 37.03, P <0.01), that is, the lower respiratory tract infection Sensitivity to indicators of lower respiratory tract infection is higher than the WBC + ESR comprehensive indicators to determine. After treatment, the sensitivity of CRP was 49.18%, the sensitivity of WBC + ESR composite index was 0.33%, the two indexes were judged by χ2 test, the difference was statistically significant (χ2 = 26.04, P <0.01), after treatment of lower respiratory tract infection The sensitivity of using CRP index to determine the lower respiratory tract infection is still higher than the WBC + ESR comprehensive index judgment. Conclusion CRP levels combined with the patient’s symptoms and signs can guide the treatment of lower respiratory tract infection. C-reactive protein in patients with lower respiratory tract infection in the judgment and efficacy than blood and ESR sensitive and effective, can be used as indicators to observe the efficacy and prognosis, to avoid premature antibiotic delaying the disease, but also increased the effective avoidance of overuse of antibiotics Resistance method. Can guide the rational use of antibacterial drugs and management.