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应用多聚酶链反应（ＰＣＲ）技术检测急性淋巴细胞白血病（ＡＬＬ）骨髓白血病细胞ＴＣＲγ基因重排，敏感性达１０￣（－５）水平以上。２７例急性期ＡＬＬ有２１例检测到约４００ｂｐ的扩增产物，阳性检出率为７７．８％（２１／２７）；７例完全缓解（ＣＲ）的ＡＬＬ有２例检测阳性，其中１例于检测后１．５月复发，另１例随访６个月仍ＣＲ；而其余５例检测阴性者于检测后平均随访７．１月均持续ＣＲ。提示本法对ＡＬＬＴＣＲ＿γ基因重排的检测较具普遍性，可用于其微量残留病（ＭＲＤ）的检测，对ＡＬＬ预后的判断、复发的监测可能有重要意义。
Polymerase chain reaction (PCR) was used to detect the rearrangement of TCRγ gene in acute myeloid leukemia (ALL). The sensitivity was above 10 (-5). In 27 cases of acute ALL, about 400bp amplification products were detected in 21 cases, the positive detection rate was 77.8% (21/27). In 7 cases with complete remission (CR), 2 cases were positive, of which 1 case Recurrence occurred 1.5 months after the test, and the other one was still CR 6 months after follow-up. The remaining 5 cases with negative test were followed up for an average of 7.1 months after the test. It is suggested that the detection of ALLTCR_γ gene rearrangement in this method is more universal and can be used for the detection of MRD. It may be of great significance to judge the prognosis of ALL and to monitor the relapse.