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目的探讨病毒性肝炎病人血清透明质酸酶(HA)的水平及其临床意义。方法采用电化学发光法测定132例各种病毒性肝炎病人及100例正常对照组血清HA水平,比较各组病毒性肝炎之间及与正常对照组血清HA水平差异。结果急性黄疸性肝炎组血清HA水平与正常对照组比较差异无显著性(P>0.05),两组血清HA水平与慢性肝炎轻度组、慢性肝炎中度组、慢性肝炎重度组及肝炎后肝硬化组比较差异有显著性(F=168.01,q=6.47~39.04,P<0.05)。结论动态测定血清HA水平,可作为反映慢性病毒性肝炎病人病情严重程度和预后的指标。
Objective To investigate the level of serum hyaluronidase (HA) in patients with viral hepatitis and its clinical significance. Methods The levels of serum HA in 132 cases of various viral hepatitis patients and 100 normal controls were determined by the method of electrochemiluminescence. The difference of serum HA level between the viral hepatitis groups and the normal control group was compared. Results There was no significant difference in serum HA level between acute jaundice hepatitis group and normal control group (P> 0.05). The levels of serum HA in mild jaundice hepatitis group were lower than those in mild chronic hepatitis group, moderate chronic hepatitis group, severe chronic hepatitis group and posthepatitic hepatitis group There was significant difference between the two groups (F = 168.01, q = 6.47 ~ 39.04, P <0.05). Conclusions The dynamic determination of serum HA levels can be used as an indicator of the severity and prognosis of patients with chronic viral hepatitis.