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目的探讨胃肠道间质瘤及胃肠外间质瘤的临床病理特点及免疫组化特点。方法分析14例胃肠间质瘤及胃肠外间质瘤临床资料和形态特征及免疫组化结果。结果 14例胃肠间质瘤中,男6例,女8例,年龄37岁~79岁,平均61.2岁,其中10例发生于胃,3例发生于小肠,1例发生于结肠,高度风险3例,中度风险3例,低度风险8例,梭形细胞型12例,1例上皮样细胞型,1例混合型;2例胃肠外间质瘤中,1例女性,发生于阴道壁,年龄50岁,高度风险,1例男性,发生于食管,年龄62岁,低度风险。2例胃肠外间质瘤均为梭形细胞型。免疫组化:(16例)CD34(+),12例CD117(+),15例Dog1(+),1例S-100(灶),16例Vim(+),3例SMA(灶+)。结论胃肠道间质瘤及胃肠外间质瘤均好发于中老年人,CD34、CD117、Dog1联合应用可明显提高诊断率,其风险性与肿瘤大小、发生部位及核分裂活性有关。
Objective To investigate the clinicopathological features and immunohistochemical features of gastrointestinal stromal tumors and extraintestinal stromal tumors. Methods The clinical data, morphological characteristics and immunohistochemical results of 14 cases of gastrointestinal stromal tumors and gastrointestinal stromal tumors were analyzed. Results Among the 14 cases of gastrointestinal stromal tumors, there were 6 males and 8 females, ranging in age from 37 to 79 years (average 61.2 years). Of these, 10 occurred in the stomach, 3 in the small intestine and 1 in the colon, 3 cases had moderate risk in 3 cases, low risk in 8 cases, spindle cell type in 12 cases, 1 case of epithelioid cell type and 1 case of mixed type. Among 2 cases of pituitary gland tumor, 1 case had female Vaginal wall, age 50, high risk, 1 males, occurs in the esophagus, age 62 years, with low risk. Two cases of psoas were spindle cell type. Immunohistochemistry: CD34 (+), 12 cases of CD117 (+), 15 cases of Dog1 (+), 1 case of S-100, 16 cases of Vim (+), 3 cases of SMA . Conclusion Gastrointestinal stromal tumors and extraintestinal stromal tumors are common in the elderly. The combination of CD34, CD117 and Dog1 can significantly improve the diagnosis rate. The risk is related to tumor size, site of occurrence and mitotic activity.