铜绿假单胞菌(PA)是目前临床上常见的致病菌,耐药发生率高。耐药的机制涉及外膜的低通透性、外排泵的过度表达、产生灭活酶、靶位的改变或增加等。PA的耐药往往是多方面的,常导致多耐药,给临床治疗带来严峻挑战。 Pseudomonas aeruginosa (PA) is the common clinical pathogen, high incidence of drug resistance. Resistance mechanisms involving the outer membrane of the low permeability, efflux pump overexpression, produce inactivated enzyme, the target change or increase. PA resistance is often multifaceted, often leading to multi-drug resistance, to bring serious challenges to clinical treatment.