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应用逐步多元线性回归方法，对紫杉醇及其衍生物的两个异构体系进行了构效关系研究，发现Ｃ１３位侧链中的Ｃ３＇位取代基的摩尔折射与其活性密切相关，从而可以推断出Ｃ３′位取代基的改变很可能是其生物活性变化的重要因素，这为设计与合成活性较高的紫杉醇类似物将提供有价值的参考信息。
A stepwise multiple linear regression method was used to study the structure-activity relationship between the two isomeric systems of paclitaxel and its derivatives. It was found that the molar refraction of the C3′ substituent in the side chain of C13 is closely related to its activity, and it can be inferred that The change of C3′-substituent is likely to be an important factor in the change of its biological activity, which will provide valuable reference information for the design and synthesis of paclitaxel analogues with higher activity.