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作者以前从系统性硬皮病(SD)患者尿中分离出一种葡萄糖氨基烯糖(Glycosaminoglycan GAG)能引起鼠硬皮病样改变。本文报告用淋巴细胞转化试验来检查细胞免疫对尿GAG的反应。作者共检查了31例SD,4例SLE,4例皮肌炎和11例健康对照者周围血的淋巴细胞。结果:在已经过氚化胸腺嘧啶核甙结合的SE患者的淋巴细胞中加入0.5M氯化钠组分的SD尿时,13例激活数值为2.20±1.72,7例正常对照者为0.89±0.20(P<0.05)。0.5及0.8M氯化钠组
The authors previously isolated a glycosaminoglycan (GAG) from the urine of patients with systemic scleroderma (SD) to cause a pathological change in the mouse scleroderma. This article reports the use of lymphocyte transformation assays to examine the response of cellular immunity to urinary GAG. The authors examined a total of 31 peripheral blood lymphocytes from SD, 4 SLE, 4 dermatomyositis and 11 healthy controls. Results: When SD of 0.5M sodium chloride fraction was added to lymphocytes of patients with tritiated thymidine-binding SE, the activation value of 13 cases was 2.20 ± 1.72 and that of 7 normal controls was 0.89 ± 0.20 (P <0.05). 0.5 and 0.8 M sodium chloride groups