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中国临床研究最常用的棉酚治疗方案(负荷量20mg/日,维持量40～60mg/周)可引起两种主要副作用:血钾降低及生殖上皮的不可逆性损害。为确定棉酚治疗的最小有效量(即该剂量既达到最大抗生育效果又产生最少副作用),作者设计了系列研究方案。本研究旨在应用微量棉酚(10mg/日,服用三个月),观察药物对精液参数及肾功能的影响。作者选择3例男性,31～35岁,系证实有生育力、无泌尿生殖及内分泌疾病的志愿者。给予醋酸棉酚片(10mg/日)3个月。服药前及服药后每4周查(1)精液常规、精液果糖含量。(2)激素
The most commonly used gossypol regimen in clinical studies in China (loading 20 mg / day, maintenance 40 to 60 mg / week) can cause two major side effects: decreased serum potassium and irreversible damage to the reproductive epithelium. To determine the minimum effective dose of gossypol treatment (ie, the dose achieves both maximum anti-fertility and minimal side effects), the authors designed a series of protocols. The purpose of this study was to investigate the effect of drugs on semen parameters and renal function using microglucan (10 mg / day for three months). The author chooses 3 males, 31-35 years old, the Department of fertility confirmed, no genitourinary and endocrine diseases volunteers. Gossypol acetate tablets (10 mg / day) were given for 3 months. Before treatment and medication every 4 weeks after check (1) semen routine, semen fructose content. (2) hormones