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肥厚型心肌病患者常有心肌缺血和心功能不全的症状和体征.心肌肥厚和左室压增高为其原因.然而IMCA细小血管(外径<1500μ)发生病变,以管壁增厚、内径大多窄小为特征.作者对平均死亡年龄29(11～60)岁的48(男21、女27)例肥厚型心肌病心脏标本的左室中段三处组织块(室间隔,前、后游离壁)进行组织学检查.以平均死亡年龄48(13～80)岁的左室肥大(扩张型心肌病8例、冠心病18例、主动脉瓣病变15例和高血压13例)和心脏正常(14例)的68(男47、女21)例心脏标本为对照.探讨IMCA病变发生率和程度、及其与临床表现的关系.测值以均值±标准误表示之.
Hypertrophic cardiomyopathy patients often have symptoms and signs of myocardial ischemia and cardiac dysfunction, cardiac hypertrophy and increased left ventricular pressure for its cause, however, IMCA small blood vessels (diameter <1500μ) lesions occur, the wall thickening, diameter Most of them are small and narrow.There are three tissue segments in the left ventricular middle segment (interventricular septum, anterior and posterior free) in 48 (21 males, 27 females) hypertrophic cardiomyopathy patients with a mean age of death ranging from 29 to 11 years old (Left ventricular hypertrophy), left ventricular hypertrophy (dilated cardiomyopathy in 8, coronary heart disease in 18, aortic valve disease in 15 and hypertension in the mean age at death from 48 to 13 years old) and normal heart (14 cases) of 68 (male 47, female 21) cases of heart specimens as a control.Immunohistochemical study of the incidence and extent of IMCA lesions, and its relationship with clinical manifestations measured values ?? mean ± standard error.