多发性骨髓瘤的特征是骨损伤 ,它常常导致疾病的衰弱性表征 ,如疼痛、高钙血症、骨质疏松、病理性骨折和脊椎受压等。这些临床表征不仅仅与骨髓瘤在骨上的沉积有关 ,还可以增加骨质疏松的程度。即使化疗成功也不能修复骨骼 ,造成骨质疏松和病理性骨折的危险依然存在。从化学角 Multiple myeloma is characterized by bone damage, which often leads to debilitative characterization of the disease, such as pain, hypercalcemia, osteoporosis, pathological fractures, and spinal compression. These clinical characterizations are not only related to the deposition of myeloma on bone, but also increase the degree of osteoporosis. Even if the chemotherapy is successful, the bone cannot be repaired, and the risk of osteoporosis and pathological fracture still exists. From the chemical angle