论文部分内容阅读
金褐霉素是从我国土壤中分离得到的链霉菌 R-22所产生的一种抗真菌物质,对多种酵母型及菌丝型真菌有作用,但对细菌无作用。链霉菌 R-22经分类鉴定证明为一株新的链霉菌,命名为金褐链霉菌(Streptomyces aureofuscus n.sp.)。金褐霉素经理化性质的研究证明是一个新的四烯类抗菌素。它的急性毒性:对小白鼠 LD_(50)腹腔注射为24.68±2.36毫克/公斤,静脉注射为28.27±2.49毫克/公斤。金褐霉素目前在临床上用于治疗真菌性角膜溃疡,有明显的疗效。
Corynebacterium is an antifungal substance produced by Streptomyces R-22 isolated from the soil of our country. It acts on a variety of yeast and mycelial fungi but has no effect on bacteria. Streptomyces R-22 was identified as a new strain of Streptomyces aureofusus n.sp. The research on the chemical nature of cinnamic acid shows that it is a new tetraene antibiotic. Its acute toxicity: intraperitoneal injection of LD_ (50) in mice was 24.68 ± 2.36 mg / kg and intravenous injection was 28.27 ± 2.49 mg / kg. Corynebacterium is currently used in clinical treatment of fungal corneal ulcer, a clear effect.