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目的:分析重庆市万州区药品不良反应(ADR)发生的特点及引发ADR的相关因素,为临床合理用药提供依据。方法:对2008年6月—2010年12月1 078例ADR报告进行归纳和分析。结果:涉及药品217种,抗感染药引起的ADR为514例,占47.7%,其次为中成药和抗肿瘤药,分别为118、95例,占10.9%、8.8%;给药途径方面,以静脉注射致ADR为主,有831例,占77.1%;临床表现以全身或局部皮肤损害为最常见,有380例次,占33.8%;新的和严重的ADR共122例,占11.3%。结论:ADR的发生与多种因素有关,除科学开展ADR监测工作外,健全监督管理机制、规范操作、合理用药,可减少ADR的重复发生。
Objective: To analyze the characteristics of adverse drug reaction (ADR) in Wanzhou District of Chongqing and the related factors of ADR, so as to provide basis for clinical rational drug use. Methods: A total of 1078 cases of ADR from June 2008 to December 2010 were summarized and analyzed. Results: A total of 217 medications involving 217 anti-infective drugs were reported, accounting for 47.7% of ADRs, followed by proprietary Chinese medicines and antitumor drugs, accounting for 10.9% and 8.8% respectively. In terms of route of administration, There were 831 cases (77.1%) with ADR caused by intravenous injection. The most common manifestations were general or partial skin lesions with 380 cases (33.8%). A total of 122 new and serious ADR cases (11.3%) were found. Conclusion: The occurrence of ADR is related to many factors. In addition to carrying out the monitoring of ADR in a scientific way, it is necessary to improve the supervision and management mechanism, standardize the operation and make rational use of drugs to reduce the recurrence of ADR.