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1SARS的免疫发病机理SARS是21世纪新发现的由SARS冠状病毒(SARS-COV)引起的传染性肺炎,对其发病机理尚不清楚,目前根椐临床、核酸水平的SARS-COV检测、尸体解剖、超微结构研究认为:SARS-COV由呼吸道进入人体,在呼吸道黏膜上皮内复制,侵犯气管上皮细胞、肺泡上皮细胞,进而引起病毒血症。在肺泡上皮细胞和肺血管内皮细胞受累时损伤呼吸黏膜的血气屏障,同时伴有炎性充血水肿、浆液、纤维蛋白原的大量渗出,渗出的纤维蛋白原凝固成纤维素,与坏死的肺泡上皮碎屑共同形成透明膜。机体对SARS-COV感染的反应可表现为肺间质内有巨噬细胞和淋巴细胞渗出,激活的巨噬细胞和淋巴细胞可释放细胞因子和自由基,进一步增加肺泡毛细血管的通透性和诱
1 SARS immune pathogenesis SARS is a newly discovered infectious pneumonia caused by the SARS coronavirus (SARS-COV) in the 21st century. The pathogenesis of SARS is not yet clear. At present, clinical and nucleic acid levels of SARS-COV detection and autopsy Ultrastructural studies suggest that SARS-COV enters the human body through the respiratory tract and replicates in the epithelial mucosa of the respiratory tract, invading the epithelial cells of the trachea and alveolar epithelium, causing viremia. In the alveolar epithelial cells and pulmonary vascular endothelial cell damage involving the respiratory mucosa when the gas barrier, accompanied by inflammatory congestion and edema, serous, fibrinogen exudation, exudation of fibrinogen solidified into cellulose, and necrosis Alveolar epithelial debris together form a transparent membrane. The body’s response to SARS-COV infection can be manifested by exudation of macrophages and lymphocytes in the interstitial lungs. Activated macrophages and lymphocytes release cytokines and free radicals, further increasing the permeability of alveolar capillaries And lure