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背景与目的:食管癌放疗后并发症特别是肺部并发症是是胸外科治疗领域中的难点之一。我们通过研究食管癌放射治疗后肺组织的损伤程度及临床病理特征,以期为临床更好的治疗提供理论基础。方法:对我院食管癌放射治疗后再手术的部分病例,手术中于放射野和非放射野分别取肺组织标本,术后进行光镜及电镜检查观察组织结构变化。结果:同期放射野和非放射野肺组织变化基本一致,主要呈急性及亚急性反应和慢性纤维化反应。结论:食管癌放疗时两肺虽有屏蔽,但从观察结果来看,放射野与非放射野同期病理变化大致相同,随放射治疗的剂量和病程的不同呈现急性、亚急性和慢性炎症反应过程。
Background and Objective: Post-radiotherapy complications of esophageal cancer, especially pulmonary complications, are one of the difficulties in the field of thoracic surgery. We study the esophageal cancer after radiotherapy of lung tissue damage and clinicopathological features, in order to provide a theoretical basis for better clinical treatment. Methods: Some cases of reoperation after esophageal cancer radiotherapy in our hospital were treated with radioactive and non-radioactive field respectively. Pulmonary tissue samples were taken after operation. The changes of tissue structure were observed by light microscopy and electron microscopy. Results: The changes of lung tissue in the same period of radiotherapy and non-radiotherapy were basically the same, mainly acute and subacute reaction and chronic fibrosis. Conclusions: Although the two lungs are shielded during esophageal cancer radiotherapy, from the observation results, the pathological changes of radiation field and non-radiation field at the same period are roughly the same. The course of acute, subacute and chronic inflammatory reaction appears with the dose and duration of radiation therapy .