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类风湿性关节炎(RA)的免疫异常,包括与体液免疫有关的质和量的异常,即出现各种自身抗体和补体成分的变化,以及免疫细胞的质和量的异常,即各种免疫细胞的机能异常及T、B 淋巴细胞比例的变化,这种变化往往同时出现。RA 为免疫复合物病,所以还有免疫复合物的检出及有关补体成分的定量变化。上述各种变化是RA 的起因,还是结果,目前尚不清楚,但免疫异常与RA 病因有直接关系是基本肯定的。一、体液免疫异常(一)类风湿因子(RF)RA 患者存在着对IgG 有特异的抗体,称为类风湿因子(RF)。这主要是19SIgM 分子。
Immunologic abnormalities of rheumatoid arthritis (RA), including abnormalities of mass and quantity related to humoral immunity, that is, changes of various autoantibodies and complement components, and abnormalities of mass and quantity of immune cells, that is, various immunizations Cell dysfunction and T, B lymphocyte ratio changes, this change often appear at the same time. RA is an immune complex disease, so there are also detection of immune complexes and quantitative changes in complement components. The above changes are the causes of RA, or the result is not yet clear, but the relationship between immune abnormalities and the etiology of RA is almost certain. First, the humoral immune abnormalities (a) rheumatoid factor (RA) RA patients there is a specific IgG antibodies, known as rheumatoid factor (RF). This is mainly 19SIgM molecules.