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一、副作用及其发生机理 1、感染症的诱发与加重 长期给糖皮质激素(以下简称GC)会引起机会感染和末期感染,往往并发肺炎、败血症或脑膜炎。就其并发感染的致病菌来看,G~+球菌感染和结核病的并发大为减少,G~-杆菌、深部真菌及病毒近来受到重视。一般认为,GC抑制巨噬细胞的游走和异物吞噬能力,且既促进免疫细胞的分化,又作用于淋巴因子系统来抑制白细胞介素1(IL1)及IL_2,结果抑制了免疫细胞的功能。
First, the side effects and its mechanism 1, induced infection and aggravate Long-term to glucocorticoid (hereinafter referred to as GC) can cause opportunistic infections and end-stage infections, often complicated by pneumonia, sepsis or meningitis. In terms of its concurrent infection of pathogens, G ~ + cocci infection and tuberculosis greatly reduced the concurrent, G ~ - bacteria, deep fungi and viruses have recently been valued. It is generally believed that GC inhibits the migration of macrophages and phagocytosis of foreign bodies, and not only promotes the differentiation of immune cells, but also acts on the lymphokine system to inhibit interleukin-1 (IL1) and IL-2, and consequently inhibits the function of immune cells.