脓毒症是临床危重患者的主要死亡原因之一,已成为现代危重病医学亟待解决的重大难题。以往脓毒症的不良预后一直归结为诊断错误或不及时,以及抗炎治疗不充分,现在人们认识到脓毒症临床表型及治疗反应不同与其遗传基因背景的差异可能有内在联系。免疫相关基因多态性(ppl-ymorphism)在一定程度上决定了机体免疫应答状态的差 Sepsis is one of the main causes of death in critically ill patients and has become a serious problem to be solved urgently in modern critically ill medicine. In the past, the poor prognosis of sepsis has been attributed to incorrect or improper diagnosis and inadequate anti-inflammatory regimens, and now it is recognized that the clinical phenotype and response to sepsis may be intrinsically linked to differences in their genetic background. The immune-related gene polymorphism (ppl-ymorphism) to a certain extent, the immune response to determine the poor state