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目的探讨肠易激综合征(IBS)的临床治疗方法,观察谷氨酰胺联合曲美布汀片口服治疗的效果。方法将158例肠易激综合征患者随机分为两组,A组应用谷氨酰胺联合曲美布汀,B组应用黄连素联合金双歧胶囊,进行2周治疗观察,观察两组患者腹痛、腹胀、腹泻的轻重程度及发作频率的变化,记录不良反应。结果两组患者单项症状计分和总症状计分均明显下降,临床症状均有改善,总有效率及对腹泻的疗效A组高于B组(86.08%vs 72.15%;87.34%vs83.54%),但差异无统计学意义(P>0.05);对腹痛、腹胀的疗效A组优于B组(92.41%vs 60.76%;91.14%vs63.29%),差异有统计学意义(P<0.05)。结论谷氨酰胺联合曲美布汀组能明显改善IBS的症状,安全有效。
Objective To investigate the clinical treatment of irritable bowel syndrome (IBS) and to observe the effect of glutamine combined with trimebutine tablets for oral treatment. Methods 158 cases of irritable bowel syndrome patients were randomly divided into two groups, A group with glutamine combined with trimebutine, B group with berberine combined with Jinshuangqi capsule for 2 weeks of treatment observed two groups of patients with abdominal pain, abdominal distension , Severity of diarrhea and seizure frequency changes, record adverse reactions. Results The score of single symptom and total symptom in both groups were significantly decreased, the clinical symptoms were improved, the total effective rate and the effect on diarrhea were higher in group A than in group B (86.08% vs 72.15%; 87.34% vs 83.54% ), But the difference was not statistically significant (P> 0.05). The effect on abdominal pain and bloating in group A was better than that in group B (92.41% vs 60.76%; 91.14% vs63.29%, P <0.05) ). Conclusion Glutamine combined with trimebutine group can significantly improve the symptoms of IBS, safe and effective.