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目的:探讨急性有机磷农药中毒(AOPP)院前救治方面的应用策略。方法:符合入选标准的急性有机磷农药中毒患者78例,按照中毒程度分为轻度中毒(16例)、中度中毒(49例)和重度中毒(13例),分别将中毒程度不同的患者随机分为治疗组和对照组。在一般治疗的基础上,治疗组给予长托宁治疗,对照组给予阿托品治疗。观察各治疗组(长托宁化的时间)和对照组(阿托品化的时间)、症状消失时间、药物中毒情况和并发症。结果:中毒程度不同的患者治疗组与对照组比较差异无统计学意义,轻中度中毒患者治疗组症状消失时间与对照组比较差异无统计学意义,而重度中毒患者治疗组症状消失时间与对照组比较差异有统计学意义。结论:根据中毒程度的不同采取不同的院前救治策略,在治疗效果和并发症的发生上长托宁明显优于阿托品。
Objective: To explore the strategy of prehospital treatment of acute organophosphorus pesticide poisoning (AOPP). Methods: Seventy-eight acute organophosphorus pesticide poisoning patients who met the inclusion criteria were divided into mild poisoning (16 cases), moderate poisoning (49 cases) and severe poisoning (13 cases) according to the degree of poisoning. Patients with different degrees of poisoning Randomly divided into treatment group and control group. On the basis of general treatment, the treatment group was treated with penehyclidine and the control group was treated with atropine. Each treatment group (the long tranquilization time) and the control group (atropine time), symptoms disappear time, drug poisoning and complications. Results: There was no significant difference between the treatment group and the control group in patients with different degrees of poisoning. There was no significant difference in the disappearance time of symptoms between the mild and moderate poisoning patients and the control group, while the disappearance time of the symptoms in the severe poisoning patients was not significantly different from the control group The difference between the two groups was statistically significant. Conclusions: Different pre-hospital treatment strategies are adopted according to the degree of poisoning, and the long-acting tonnage is superior to atropine in the treatment effect and complications.