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目的利用CT、MRI动态监测兔VX2肝癌生长情况,了解不同时期VX2肝癌的CT和MRI表现特点。方法移植法建立10只兔VX2肝癌模型(共20个病灶),种植后1、2、3周行肝脏螺旋CT平扫、双期增强检查及MRI平扫和增强检查。结果种植后1周肿瘤CT、MRI检出率低,2周后上升至100%。平扫CT肿瘤表现为均匀低密度灶;注药后动脉期肿瘤显示为边缘环行强化,而肿瘤主体保持为低密度,其中14例(70%)肿瘤可见肿瘤供养肝动脉直达病灶边缘,9例(45%)肿瘤显示瘤内动脉血管;门静脉期病变降为低密度。T1WI和T2WI肿瘤分别表现为低信号和稍高信号,增强后同样呈边缘环行强化。种植后3周平扫CT、MRI显示肿瘤密度或信号变为不均匀。结论兔VX2肝癌为少血供肿瘤,CT、MRI检查可有效监测VX2肝癌生长情况。
OBJECTIVE: To dynamically monitor the growth of VX2 liver cancer in rabbits by using CT and MRI, and to understand the CT and MRI features of VX2 liver cancer at different stages. Methods Ten rabbit models of VX2 hepatocellular carcinoma (20 lesions) were established by transplantation. Spiral CT scan, double-phase enhanced MRI and MRI plain scan and enhanced MRI were performed at 1, 2 and 3 weeks after implantation. Results One week after planting, the detection rate of tumor CT and MRI was low, rising to 100% after 2 weeks. Tumors in the CT scan showed homogeneous low-density lesions. Arterial tumors showed enhanced peripheral circulation and low density of the main tumor after injection, of which 14 (70%) tumors showed hepatic artery directly to the edge of the lesion and 9 (45%) tumors showed intratumoral arterial blood vessels; portal venous disease reduced to low density. T1WI and T2WI tumors showed low signal and slightly high signal, respectively, enhanced by the same ring edge enhancement. Three weeks after planting plain CT, MRI showed tumor density or signal becomes uneven. Conclusions Rabbit VX2 liver cancer is less blood supply to the tumor. The CT and MRI examination can effectively monitor the growth of VX2 liver cancer.