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妊娠滋养细胞疾病是一种与妊娠密切相关的疾病,其本质就是胎盘绒毛细胞变性或过度增生,近年来癌基因、抑癌基因在滋养细胞的增殖、分化、转移及滋养细胞疾病的预后中的作用受到密切的关注,最常见的癌基因有bcl-2、c-myc、mdm2和抑癌基因p53以及增殖细胞抗原(PCNA)。将其在正常妊娠过程中的表达及作用以及与妊娠滋养细胞疾病的发生、发展、预后的关系进行综述。
Gestational trophoblastic disease is a pregnancy-related diseases, its essence is the placental villus degeneration or hyperplasia, in recent years, oncogenes, tumor suppressor genes in the proliferation of trophoblast differentiation, metastasis and prognosis of trophoblastic disease The effects are closely watched. The most common oncogenes are bcl-2, c-myc, mdm2, and the tumor suppressor p53 and proliferating cell antigens (PCNA). The relationship between the expression and the role in the process of normal pregnancy and the occurrence, development and prognosis of gestational trophoblastic diseases were reviewed.