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目的:分析肝病患者血清HA、LN、IV-C、PCⅢ水平与临床分型及病理分期的关系。方法:对200例肝病患者(其中98例采用肝活检确诊)分别采用放免法测定血清HA、LN、IV-C、PCⅢ水平。结果:血清HA、LN、IV-C水平在慢性肝炎中度和病理S_3期时开始明显高于对照组(P<0.05),但PCⅢ水平在病理S_2期就开始明显高于对照组(P<0.05),且随着肝脏炎症和纤维化程度的加重而升高。结论:血清HA、LN、IV-C、PCⅢ水平可反映肝纤维化程度,而且受肝脏炎症程度的影响。PCⅢ似是判断早期肝硬化的相对灵敏和可靠指标。
Objective: To analyze the relationship between serum levels of HA, LN, IV-C and PCⅢ in patients with liver disease and clinical classification and pathological stage. Methods: Serum HA, LN, IV-C and PCⅢ levels were measured by radioimmunoassay in 200 cases of liver disease (98 cases were diagnosed by liver biopsy). Results: Serum levels of HA, LN and IV-C were significantly higher in patients with moderate chronic hepatitis and S_3 stage than those in control group (P <0.05), but PCⅢ level was significantly higher in S 2 stage than that in control group (P < 0.05), and increased with the severity of liver inflammation and fibrosis. Conclusion: The levels of serum HA, LN, IV-C and PCⅢ can reflect the degree of liver fibrosis and are affected by the degree of liver inflammation. PC Ⅲ seems to determine the relative sensitivity and reliability of early cirrhosis.