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目的研究慢性阻塞性肺疾病(COPD)患者血清一氧化氮(NO)和肾上腺髓质素(ADM)的变化及意义。方法选择COPD急性加重期患者50例,分为Ⅰ级、Ⅱ级、Ⅲ级、Ⅳ级4组,应用硝酸还原酶法测定NO,酶联免疫吸附法测定肾上腺髓质素(ADM)水平,并记录动脉血气分析、肺功能等指标。同时与13例健康者进行对照。结果①COPD组血清NO较对照组显著降低,差异具有统计学意义(P<0.01),COPD组较对照组显著增高,差异具有统计学意义(P<0.01);②血清NO、ADM值随COPD分级增高而变化,且组间差异有统计学意义(P<0.05);③NO与FEV1、PaO2呈正相关,与PaCO2呈负相关;ADM与FEV1、PaO2呈负相关,与PaCO2呈正相关;NO与ADM呈负相关。结论 NO和ADM作为肺脏重要的舒血管因子,以不同的方式参与和影响了COPD的发生和发展。
Objective To study the changes and significance of serum nitric oxide (NO) and adrenomedullin (ADM) in patients with chronic obstructive pulmonary disease (COPD). Methods Fifty patients with acute exacerbation of COPD were divided into four groups (Ⅰ, Ⅱ, Ⅲ, Ⅳ). Nitric acid reductase (NO) was used to determine the level of adrenomedullin (ADM) and enzyme linked immunosorbent assay Record arterial blood gas analysis, lung function and other indicators. At the same time with 13 healthy controls. Results ① The NO level in COPD group was significantly lower than that in control group (P <0.01), and the COPD group was significantly higher than that in control group (P <0.01) (P <0.05); ③NO was positively correlated with FEV1, PaO2 and negatively correlated with PaCO2; ADM was negatively correlated with FEV1, PaO2 and positively correlated with PaCO2; NO and ADM were significantly increased Negative correlation. Conclusion NO and ADM, as important vasodilator factors in lung, participate and influence the occurrence and development of COPD in different ways.