论文部分内容阅读
以大孔型聚苯乙烯树脂为骨架材料,先引入醛基,再进一步与乙二醇二流基乙酸酯等巯基化合物反应,生成具缩硫醛大环的螯合树脂,产物对Hg~(+2)络合容量约为30—60mg/g,比文献报导的缩聚型缩硫醛大环螯合树脂高约十倍。其对汞的络合容量比对Ca~(+2)、Mg~(+2)、Zn~(+2)、Cd~(+2)、Co~(+2)等高约两个数量级。 又采用右旋糖苷为载体合成了一种水溶性的大分子缩硫醛大环螯合剂,产物使因汞中毒而失活的脲酶恢复活力的能力很强。通过一系列动物实验验证了药物本身的中毒性极低并具有一定的解汞毒能力。又采用同位素示踪技术研究了药物在小白鼠体内的代谢
Macroporous polystyrene resin as the framework material, the first introduction of aldehyde groups, and further ethylene glycol bishydroxyacetate and other mercapto compounds, resulting in a thiazole acetal macrocyclic chelate resin, the product of Hg ~ ( +2) complexing capacity is about 30-60mg / g, which is about ten times higher than that reported in the literature. The complexing capacity of mercury is about two orders of magnitude higher than that of Ca 2+, Mg 2+, Zn 2+, Cd 2+ and Co 2+. And dextran was used as a carrier to synthesize a water-soluble macrocyclic mercaptals macrocyclic chelating agent, the product of mercury poisoning deactivation of urease has a strong ability to restore vitality. Through a series of animal experiments to prove the drug itself is extremely low toxicity and has some ability to detoxification. Also used isotope tracer technology to study the metabolism of drugs in mice