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目的:观察中药联合甲氨蝶呤治疗剖宫产疤痕妊娠的安全性及其临床疗效。方法:将53例诊断为剖宫产疤痕妊娠有明确保守治疗指征的患者随机分为2组,治疗组24例采用中药联合甲氨蝶呤治疗,对照组29例使用甲氨蝶呤治疗,观察2组用药后血β-绒毛膜促性腺激素(β-HCG)含量、药物不良反应等。结果:治疗组治疗后没有重复肌肉注射甲氨蝶呤的患者,治疗2、7天血β-HCG含量、治疗7天孕囊直径等均较对照组同时段改善明显,差异均有显著性意义(P<0.05)。治愈率治疗组为87.50%,对照组为62.07%,2组比较,差异有显著性意义(P<0.05)。不良反应发生率治疗组为8.33%,对照组为34.48%,2组比较,差异有显著性意义(P<0.05)。结论:中药联合甲氨蝶呤治疗剖宫产疤痕妊娠疗效比单独使用甲氨蝶呤好,且用药安全,不良反应发生率低。
Objective: To observe the safety of traditional Chinese medicine and methotrexate in the treatment of cesarean scar pregnancy and its clinical efficacy. Methods: 53 patients diagnosed as cesarean scar pregnancy with conservative treatment indications of patients were randomly divided into two groups, the treatment group of 24 patients treated with Chinese medicine combined methotrexate, the control group of 29 patients treated with methotrexate, After treatment, blood β-HCG levels and adverse drug reactions were observed. Results: The patients in the treatment group who did not receive intramuscular methotrexate intramuscularly after treatment had significantly better serum β-HCG content at 2 and 7 days and gestational sac diameter at 7 days than those in the control group, the differences were significant (P <0.05). The cure rate was 87.50% in the treatment group and 62.07% in the control group. There was significant difference between the two groups (P <0.05). The incidence of adverse reactions was 8.33% in the treatment group and 34.48% in the control group. There was significant difference between the two groups (P <0.05). Conclusion: The curative effect of traditional Chinese medicine combined with methotrexate on cesarean scar pregnancy is better than methotrexate alone, and the medication is safe and the incidence of adverse reactions is low.