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防变异浓度 (MPC)是指抗菌药物防止细菌选择第一步耐药突变的最低浓度 ,MPC与MIC(最小抑菌浓度 )的浓度范围为突变选择窗 (MSW )。当血清或组织液药物浓度低于MIC时 ,治疗无效但也不会导致细菌耐药突变体的富集 ;超过MPC时细菌要生长须同时具备两种或以上突变 ,因而不仅治疗成功并且也很难出现耐药突变体的选择性扩增 ;处于窗内时将选择出耐药突变菌 ,即使临床治疗成功率很高。该理论为有效抑制细菌耐药及制定抗菌药物应用策略提供了新的思路和参考依据。
Anti-variant concentration (MPC) is the lowest concentration of antibacterial drug to prevent the first step of drug-resistant mutations in bacterial selection. The concentration range of MPC and MIC (Minimal Inhibition Concentration) is mutation selection window (MSW). Treatment is ineffective but does not result in enrichment of bacterial resistant mutants when serum or tissue fluid drug concentrations are lower than MICs; mutations exceeding two or more are necessary for the growth of bacteria beyond MPC, making treatment not only successful but also difficult There is selective amplification of drug-resistant mutants; resistant mutants will be selected in the window, even if the success rate of clinical treatment is high. The theory provides a new idea and reference for the effective inhibition of bacterial resistance and the development of antimicrobial application strategies.