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血管病变在系统性硬化症(SS)中很常见,其中95%的患者在疾病的某个阶段有雷诺氏现象。急性局部缺血性损害很少见,但一旦发生,却是一严重的并发症,很难治疗。本文报告经静脉输注己酮可可硷有效地治疗了2例 SS 引起的肢端坏疽病人。例1.女,70岁,长期患 SS(有皮损,雷诺氏现象、高血压及心肺受累),一只手的3个指尖及另一只手的1个指尖有多个坏疽性损害,除口服心痛定(直至10mg,每日3次)外,需麻醉止痛,之后予静脉输注前列环素(最大滴速为48小时内9μg/kg/min),但继续出现新损
Vascular lesions are common in systemic sclerosis (SS), with 95% of them having Raynaud’s phenomenon at some stage of the disease. Acute ischemic damage is rare, but in the event of a serious complication, it is difficult to treat. This article reports the intravenous infusion of pentoxifylline effective treatment of 2 cases of limb gangrene caused by SS patients. Example 1. Female, 70 years old with long-term SS (skin lesions, Raynaud’s phenomenon, hypertension and cardiopulmonary involvement), 3 fingertips in one hand and 1 gangbang in one fingertip of the other hand In addition to oral administration of nifedipine (up to 10 mg, 3 times daily), anesthesia and analgesia were required, followed by intravenous infusion of prostacyclin (maximum drip rate of 9 μg / kg / min within 48 hours)