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目的研究血管紧张素Ⅱ受体拮抗剂替米沙坦对老年收缩期高血压左心室舒张功能的影响。方法采用自身对照开放试验方法,56例原发性收缩期高血压伴左心室舒张功能不全的老年患者口服替米沙坦80~160mg,1次/d,治疗12个月后,对治疗前后进行超声多普勒左心舒张功能测量与对照分析。结果与治疗前相比,56例高血压患者治疗12个月后,血压显著下降(P<0.01);超声多普勒对照检查显示,左室后壁舒张末期厚度(LVPWT)、室间隔舒张末期厚度(IVST)、峰值充盈速度A、峰值速度A峰/值速度E比值均明显下降(P<0.01)。结论替米沙坦在降压的同时,能有效地改善左心室舒张功能。
Objective To investigate the effect of telmisartan, an angiotensin Ⅱ receptor antagonist, on left ventricular diastolic function in elderly patients with systolic hypertension. Methods Self-controlled open-label test was used in 56 elderly patients with essential systolic hypertension and left ventricular diastolic dysfunction who were treated with Telmisartan 80 ~ 160mg once daily for 12 months before and after treatment Measurement and contrast analysis of left ventricular diastolic function by Doppler echocardiography. Results Compared with that before treatment, blood pressure was significantly decreased in 56 hypertensive patients after 12 months of treatment (P <0.01). Contrast-enhanced ultrasound Doppler ultrasound showed that left ventricular posterior wall end-diastolic thickness (LVPWT), interventricular septum IVST, peak filling velocity A, peak velocity A peak / velocity E ratio decreased significantly (P <0.01). Conclusion Telmisartan can decrease left ventricular diastolic function effectively while lowering blood pressure.