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目的 :了解绒毛膜促性腺激素 (HCG)治疗小阴茎患儿的远期疗效。方法 :83例经临床确诊的小阴茎患儿 ,年龄 3～ 15岁 ,平均 9 3岁 ,予以肌肉注射HCG治疗。每疗程总量为 10 0 0u,一个疗程疗效不佳者 3月后再重复一个疗程。所有患儿均接受随访。随访期限 1月～ 3年 ,平均 1 5年。随访资料包括 :随茎长度 ,直径 ,血清睾酮 ,黄体生成素 ,卵泡刺激素 ,β-绒毛膜促性腺激素 ,并取同年龄组正常儿童作对照。结果 :随访资料完整者 71例 ,其中 6 6例患儿治疗后阴茎长度较治疗前明显增长 (P <0 0 1) ,同时血清睾酮也有明显上升 ,而黄体生成素 ,卵泡刺激素及 β-绒毛膜促性腺激素水平无明显变化。另 5例患儿阴茎长度虽有所增加 ,但与治疗前相比无统计学差异。其中 2例患儿血清睾酮上升 ,另 3例患儿血清睾酮无明显变化。结论 :HCG对小阴茎患儿有着较为满意的远期治疗效果
Objective: To understand the long-term efficacy of human chorionic gonadotropin (HCG) in treating children with small penis. Methods: 83 cases of small penile clinically diagnosed children, aged 3 to 15 years, mean 93 years, intramuscular HCG treatment. The total amount of each treatment is 10 0u, a course of treatment is not good after 3 months and then repeat a course of treatment. All children were followed up. Follow-up period of January to 3 years, an average of 15 years. Follow-up data included: with the length of the stem, diameter, serum testosterone, luteinizing hormone, follicle stimulating hormone, β-chorionic gonadotropin, and take the same age group normal children as a control. Results: The follow-up data were complete in 71 cases, of which 6 6 children after treatment, the penile length was significantly increased (P <0.01), while serum testosterone also increased significantly, and luteinizing hormone, follicle stimulating hormone and β- No significant changes in chorionic gonadotropin levels. The other 5 cases of children with penile length increased, but no significant difference compared with before treatment. Serum testosterone increased in 2 of them and no significant change in serum testosterone in 3 other children. Conclusion: HCG has a more satisfactory long-term therapeutic effect on children with small penis