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血小板灭活是婴幼儿先天性心脏病体外心肺转流（CPB）手术中和手术后出血的重要因素[1]。有报道认为在CPB中成人和儿童患者的循环血细胞有功能和结构改变[2],血小板被激活,释放颗粒和新抗原如 CD62和 CD63对血小板细胞膜的表达,另外,血小板膜糖蛋白Ib的表达减少。婴幼儿CPB时循环血量相对较少,因此,血小板活性和膜受体的灭活相对较多。为了探讨CPB对婴幼儿血小板反应性的影响,用全血流式细胞术（Fcy）可从小样本的全血中检测出大量的单个血小板膜受体,即血小板粘附受体膜糖蛋白Ib的表面密度和血小板激活程度,由P-选择素阳性量确定。
Platelet inactivation is an important factor in infantile congenital heart disease during cardiopulmonary bypass (CPB) surgery and postoperative bleeding [1]. It has been reported that circulating and circulating blood cells in adult and pediatric patients in CPB have functional and structural changes [2], platelets are activated, the release of particles and new antigens such as CD62 and CD63 on the platelet membrane expression, in addition, platelet membrane glycoprotein Ib expression cut back. Infant CPB relatively small amount of circulating blood volume, therefore, platelet activity and membrane receptor inactivation is relatively more. In order to investigate the effect of CPB on platelet reactivity in infants and young children, a large number of single platelet membrane receptors, ie platelet adhesion receptor membrane glycoprotein Ib, can be detected from whole blood of small samples using whole blood flow cytometry (Fcy) Surface density and platelet activation, as determined by the positive amount of P-selectin.