胰岛素抵抗是外周组织对胰岛素的敏感性及反应性降低,导致胰岛素代偿性增加,引起高胰岛素血症。近年来研究表明,不仅巨噬细胞,还有B细胞、T细胞、嗜酸性粒细胞以及肥大细胞,可以通过炎症反应调控胰岛素抵抗。因此,免疫细胞的关联研究,可能为糖尿病基础研究和诊断治疗带来新方向。 Insulin resistance is peripheral tissue on insulin sensitivity and responsiveness, resulting in compensatory increase in insulin, causing hyperinsulinemia. In recent years, studies have shown that not only macrophages, but also B cells, T cells, eosinophils and mast cells can regulate insulin resistance through inflammatory response. Therefore, the related research of immune cells may bring new directions for basic research and diagnosis and treatment of diabetes.