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评价胺碘酮对８１例慢性心房颤动患者转复后长期维持窦性心律的有效性和安全性。胺碘酮负荷量６００ｍｇ／ｄ１～２周、４００ｍｇ／ｄ１～２周，继以维持量２１５±５０ｍｇ／ｄ，服药１～２周后行电转复。９例（９／７６，１１．８４％）在胺碘酮负荷量期间转为窦性心律，７２例电转复为窦性心律，平均随访１４．５个月（０．５～９２个月）．胺碘酮维持窦性心律半年有效率７１．６％（５８／８１），１年有效率６３．０％（５１／８１），副反应发生率１１．１％（９／８１）．未见严重毒副反应，逻辑回归分析显示心功能分级为维持窦性心律的负性因素，胺碘酮为慢性心房颤动转复后维持窦性心律的有效药物，用量以较小为宜。
To evaluate the efficacy and safety of amiodarone for long-term maintenance of sinus rhythm after revitalization in 81 patients with chronic atrial fibrillation. Amiodarone loading 600mg / d1 ~ 2 weeks, 400mg / d1 ~ 2 weeks, followed by the maintenance dose 215 ± 50mg / d, taking medicine 1 to 2 weeks after the electrical conversion. Nine patients (9/76, 11.84%) were converted to sinus rhythm during amiodarone loading, and 72 patients were converted to sinus rhythm with an average follow-up of 14.5 months (0.5-92 months) . Amiodarone maintained sinus rhythm for half a year, with an effective rate of 71.6% (58/81), 63.0% (51/81) in 1 year, and 11.1% (9/81) in side effects. Logistic regression analysis showed that heart function grading was a negative factor to maintain sinus rhythm. Amiodarone was an effective drug to maintain sinus rhythm after chronic atrial fibrillation was recovered, and the dosage should be smaller.