论文部分内容阅读
肢端肥大症(acromegaly,AM)活动的诊断和临床评定,通常于禁食一夜和/或口服葡萄糖耐量试验(OGTT)后通过测定血浆生长激素(GH)以证实。但因空腹 GH 水平的自发性波动大;OGTT 时 GH 的应答可能反常;以及在某些活动性 AM 患者 GH 对OGTT 的应答呈正常结果,因此解释结果有困难。生长素介质(somatomedin,SM)的 GH 依赖性及其因与特殊载体蛋白结合使半寿期延长,提示测定 SM水平可能提供一个 GH 分泌的指标。新近 SM 胰岛素样生长因子(IGF)的提纯和竞争性结合测定法(CBA)
The diagnosis and clinical assessment of acromegaly (AM) activity are usually confirmed by measuring plasma growth hormone (GH) after a fasting overnight and / or oral glucose tolerance test (OGTT). But spontaneous fluctuations in fasting GH levels are large; GH response may be abnormal at OGTT; and GH is normally expressed as a response to OGTT in some active AM patients, explaining difficulties. The GH dependence of somatomedin (SM) and its long half-life due to binding to specific carrier proteins suggest that determining SM levels may provide an indication of GH secretion. Recent purification and competitive binding assay (CBA) of SM insulin-like growth factor (IGF)