哌唑嗪现已用于前列腺肥大症(BPH)。正常前列腺重量在10～20g之间。其重量在大多数超过40岁的男性中开始增加,最大能超过正常重量的10倍。因为其位于膀胱底部,因此会增加自然尿道阻塞,引起尿频和尿量减少。如不及时治疗可导致尿滞、肾衰、肾结石及感染等。 Milroy报道了抑制α_1受体阻滞剂哌唑嗪抑制异常肥大肌肉组织的腺体和抑制收缩的作用。减少了尿流阻力,另外有试验显示, Prazosin is now used in benign prostatic hyperplasia (BPH). Normal prostate weight between 10 ~ 20g. Its weight starts to increase in most men over the age of 40, up to 10 times the normal weight. Because it is located in the bottom of the bladder, it will increase the natural urethral obstruction, causing frequent urination and decreased urine output. If not treated can lead to urinary and renal failure, kidney stones and infections. Milroy reported inhibition of alpha 1 receptor blocker prazosin in inhibiting abnormal glandular muscle glands and inhibiting contractile effects. Reduce the urinary flow resistance, another test showed that,