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对82例胃癌作了S－P法免疫组化染色，观察p53癌基因在各型胃癌中的表达以及与其淋巴组织增生之间的关系。结果癌周淋巴细胞浸润的程度，癌引流区淋巴结反应性增生的数量与p53蛋白表达呈负相关；癌引流区淋巴结癌转移及其分期与p53蛋白表达呈正相关，p53阳性表达与胃癌组织学类型，分化程度无明显关系。
S-P immunohistochemical staining was performed on 82 cases of gastric cancer to observe the expression of p53 oncogene in gastric carcinoma and its relationship with lymphoid tissue hyperplasia. Results The degree of lymphocytic infiltration, the number of lymph node reactive hyperplasia in the draining area was negatively correlated with the expression of p53 protein. The lymphatic metastasis and staging in the cancer draining area was positively correlated with the expression of p53 protein. The positive expression of p53 and the histological type of gastric cancer. There is no obvious relationship between the degree of differentiation.