灰黄霉素作为有效的抗真菌药,在临床上早已被广泛地应用。由于它水溶性差(1∶100)故口服后吸收缓慢,半衰期为9.5～21小时。关于研究影响灰黄霉素生物利用度因素的文章,国外早有大量报道,尤其是微粒化制剂比非微粒化制剂产生高近1倍的血药浓度,脂肪餐可使灰黄霉素的吸收明显增加。但是,目前国内产品大都为非微粒化制剂(按77版中国药典标准)。因此,上海信谊药厂拟提高灰黄霉素片的生物利用 Griseofulvin has been widely used clinically as an effective antifungal drug. Due to its poor water solubility (1: 100) so after oral absorption is slow, half-life of 9.5 to 21 hours. Articles on the study of factors affecting the bioavailability of griseofulvin, foreign reports have long been reported, especially the micronized formulations than non-micronized formulations produce nearly 1 times the plasma concentration of fat meal griseofulvin absorption obviously increase. However, at present, most domestic products are non-micronized preparations (according to the 77th edition of Chinese Pharmacopoeia standards). Therefore, Shanghai Xinyi Pharmaceutical Factory plans to increase the bioavailability of griseofulvin tablets