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目的:观察应用选择性胆固醇吸收抑制剂依折麦布治疗高脂血症的临床疗效。方法:选择高脂血症患者50例,随机分为辛伐他汀组(对照组)25例和辛伐他汀加依折麦布组(治疗组)25例,治疗8周,观察2组患者治疗前后血脂变化。结果:治疗组患者血脂达标率显著优于对照组(P<0.05);2组患者治疗后TC、LDL-C较治疗前降低,且治疗组治疗后较对照组治疗后改善更加(P<0.05)。结论:应用选择性胆固醇吸收抑制剂依折麦布联合他汀类治疗高脂血症疗效显著。
Objective: To observe the clinical efficacy of selective elective cholesterol absorption inhibitor ezetimibe in the treatment of hyperlipidemia. Methods: Fifty patients with hyperlipidemia were randomly divided into simvastatin group (control group) 25 and simvastatin plus ezetimibe group (treatment group) 25 cases for 8 weeks, the two groups were treated Changes in blood fat before and after. Results: The blood lipid compliance rate of the treatment group was significantly better than that of the control group (P <0.05). The TC and LDL-C of the two groups were lower than those before treatment, and the treatment group improved more than the control group after treatment (P <0.05 ). Conclusion: The selective cholesterol absorption inhibitor ezetimibe and statins for the treatment of hyperlipidemia have a significant effect.