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为探讨循环免疫复合物(CIC)在妊高征发病中的作用,采用聚乙二醇沉淀比浊法测定了30例非孕育龄妇女,34例正常晚期妊娠和78例妊高征患者母体血清CIC水平,同时测定了10例正常妊娠和16例妊高征新生儿脐血CIC水平。结果发现中、重度妊高征血清CIC水平明显升高(P<0.01);妊高征母体血清CIC水平较其脐血CIC水平明显增高(P<0.01)。从而认为妊高征循环免疫复合物浓度升高可能是血管内皮细胞损伤的重要因素,在妊高征发病中起重要作用
To investigate the role of circulating immune complex (CIC) in the pathogenesis of PIH, the serum levels of maternal serum in 30 non-pregnant women, 34 normal pregnant women and 78 PIH patients were measured by polyethylene glycol precipitation turbidimetry CIC levels were measured at the same time, 10 cases of normal pregnancy and 16 cases of PIH neonatal cord blood CIC levels. The results showed that serum CIC levels in patients with moderate and severe pregnancy-induced hypertension were significantly increased (P <0.01). The serum CIC level in PIH maternal serum was significantly higher than that in cord blood (P <0.01). So that elevated levels of PIH immune complexes may be an important factor in vascular endothelial cell injury, plays an important role in the pathogenesis of PIH