【摘 要】
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The calicheamicins, produced by Micromonospora echinospora ssp. calichensis, were discovered in afermentation products screening program for DNA-damaging antit
【机 构】
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American Cyanamid Company Medical Research Division Lederle Laboratories Pearl River New York 10965
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The calicheamicins, produced by Micromonospora echinospora ssp. calichensis, were discovered in afermentation products screening program for DNA-damaging antitumor agents. Seven related com-ponents were isolated and characterized. The chemical structure of the major component, calicheam-icin γ_1~1, containing a bicyclic enediyne system, was determined by a combination of degradation stud-
The calicheamicins, produced by Micromonospora echinospora ssp. Calichensis, were discovered in afermentation screening programs for DNA-damaging antitumor agents. Seven related com-ponents were isolated and characterized. The chemical structure of the major component, calicheam- icin γ_1 ~ 1, containing a bicyclic enediyne system, was determined by a combination of degradation stud-
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