梭曼(soman,特己基甲基氟膦酸酯)、沙林(sarin,异丙基甲基氟膦酸酯)、维埃克斯[VX,O-乙基-S-(2-二异丙胺乙基)甲基膦酸酯]等是一类重要的神经性化学战剂,其中以梭曼中毒最难防治。它们对乙酰胆碱酯酶(AChE)产生极强的抑制作用,使乙酰胆碱在神经末梢大量集聚,引起抽筋、惊厥,最后死亡。氯磷啶、双磷啶等重活化剂是神经性毒剂中毒急救中的重要药物,它们可以使沙林和VX抑制的AChE恢复活性,但对梭曼抑制的AChE很 Soman, sarin, VEX, VX, O-ethyl-S- (2-diisopropyl) Propylamine ethyl) methyl phosphonate] is an important class of neurogenic chemical warfare agents, of which Soman’s most difficult to prevent. They have a very strong inhibitory effect on acetylcholinesterase (AChE), causing a large accumulation of acetylcholine in nerve endings, causing cramps, convulsions, and finally death. Reactivators such as chlorophosphonates and bisphosphonates are important drugs in the emergency of neurotoxic agents. They can reactivate sarin and VX-inhibited AChE, but inhibit somatic AChE