1845年Virchow确立了白血病为一种临床疾病,1856年Vidal发现本病常伴有听力障碍,Politzer(1884)首次报告一例白血病患者于死前一年发生严重的感音聋。Fraser观察4例白血病患者单侧性听力障碍,二例颞骨中有神经节的变性。Hallpike等(1950)报告一白血病患者死前 Virchow established leukemia in 1845 as a clinical disease. In 1856, Vidal found that the disease was often accompanied by hearing loss. For the first time, Politzer (1884) reported a case of leukemia with severe sensorineural hearing loss a year prior to death. Fraser observed unilateral hearing impairment in 4 patients with leukemia and in 2 patients with degeneration of the ganglia in the temporal bone. Hallpike et al. (1950) reported a leukemia patient before death