摘要目的探讨门静脉流率变化对使用双极射频消融(RF)设备所产生的消融区大小和形状的影响。材料与方法本研究已通过实验动物使用和管理委员会批准。采用牛肝体外模型,以3种流率[60、80、100 mL/(min·100 g肝脏)]通过门静脉进行自体血液灌注,每种流率下各5个肝脏标本,每个标本各制备4个消融区,双极和单极(对照)RF设备消融区各2个。通过大体标本测量短径和长径,计算得出每个消融区的体积和球形指数。采用肝脏相关性一般线性混合模型评 Abstract Objective To investigate the effect of portal venous flow rate on the size and shape of the ablation zone created by bipolar radiofrequency ablation (RF). Materials and Methods This study was approved by the Laboratory Animal Care and Administration Commission. Autologous blood perfusion was performed through the portal vein at 3 flow rates [60, 80, 100 mL / (min · 100 g of liver)] using bovine liver in vitro models with 5 liver specimens at each flow rate, each prepared 4 ablation zones, 2 bipolar and unipolar (control) RF ablation zones each. The volume and the spherical index of each ablation zone are calculated by measuring the short and long diameters in the gross specimen. The general linear mixed model of liver correlation was used to evaluate