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目的探讨小剂量胺碘酮预防非瓣膜性心脏病阵发性房颤复发的疗效和安全性。方法40例阵发性房颤患者给予胺碘酮600mg d~(-1),5日后渐减为维持量50～100mg d~(-1),采用24小时动态心电图观察评价其疗效。结果服药后6个月、12个月和24个月,安碘酮维持窦性心律的有效率分别为92.5%、81.25%和84%,因其显著窦性心动过缓(<≤5次/分)而停药者仅5%(2/40)。结论小剂量胺碘酮(50～100mg d~(-1))预防非瓣膜性心脏病阵发性房颤是有效和安全的。
Objective To investigate the efficacy and safety of low dose amiodarone in preventing recurrence of paroxysmal atrial fibrillation in patients with nonvalvular heart disease. Methods Amiodarone 600 mg d -1 was given to 40 patients with paroxysmal atrial fibrillation. After 5 days, the maintenance dose was reduced to 50-100 mg d -1. The therapeutic effect was evaluated by 24-hour Holter monitoring. Results Six months, 12 months and 24 months after treatment, the effective rates of maintaining amiodarone for sinus rhythm were 92.5%, 81.25% and 84%, respectively. Because of its significant sinus bradycardia (<≤ 5 times / Points) and stopped only 5% (2/40). Conclusions Small dose amiodarone (50 ~ 100 mg d ~ (-1)) is effective and safe in preventing paroxysmal atrial fibrillation in patients with nonvalvular heart disease.