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应用单克隆抗体建立的ELISA检测各型HBV感染者179例血清IgA抗-HBc。急性乙肝14例和重肝7例均为阳性,慢活肝50例阳性率为94％,慢活肝并肝硬化12例为83.3％,慢迁肝46例为56.5％,HBsAg无症状携带者50例为4％。提示IgA抗-HBc与肝损程度和范围密切相关,在乙肝诊断、鉴别诊断及预后判断上有一定实用价值。此外,IgA抗-HBc在慢性肝炎中与HBeAg呈正相关。
Serum IgA anti-HBc was detected in 179 HBV-infected patients by ELISA using monoclonal antibodies. 14 cases of acute hepatitis B and 7 cases of severe liver were positive, 50 cases of slow-acting liver positive rate was 94%, 12 cases of chronic active liver cirrhosis was 83.3%, 46 cases of slow-moving liver was 56.5%, HBsAg asymptomatic carriers 50 cases were 4%. Tip IgA anti-HBc is closely related with the extent and extent of liver damage in the diagnosis of hepatitis B, differential diagnosis and prognosis have some practical value. In addition, IgA anti-HBc is positively correlated with HBeAg in chronic hepatitis.