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目的:回顾性分析营养管置入并常规放疗加紫杉醇化疗治疗贲门癌并重度狭窄患者的临床效果及毒副反应。方法:回顾性分析我院2010年2月~2012年3月贲门癌并狭窄患者23例。患者均首先X线下进行营养管置入鼻饲饮食;放射治疗每周5次,每次2.0 Gy.总剂量40.0Gy。紫杉醇每周1次,40 mg/m2,持续静滴3小时。结果:23例均1完成了治疗,总有效率为100%,平均缓解期4.3个月。血液学毒性是主要不良反应,Ⅲ级4人(17.3%),Ⅳ级1人(4.3%)。结论:营养管置入并常规放疗加紫杉醇化疗治疗贲门癌并重度狭窄患者是有效的治疗方法,局部控制率好,毒副反应能够耐受。
OBJECTIVE: To retrospectively analyze the clinical effects and side effects of nutritional tube placement and routine radiotherapy plus paclitaxel chemotherapy in the treatment of cardia cancer with severe stenosis. Methods: A retrospective analysis of our hospital from February 2010 to March 2012 cardia cancer and stenosis in 23 patients. Patients were first placed under the X-ray tube into the nasogastric diet; radiation treatment 5 times a week, each 2.0 Gy. The total dose of 40.0 Gy. Paclitaxel once a week, 40 mg / m2, continuous intravenous infusion of 3 hours. Results: All 23 cases completed treatment, the total effective rate was 100% and the average remission period was 4.3 months. Hematologic toxicity was the major adverse effect, with grade 4 (17.3%) and grade 1 (4.3%). Conclusion: The nutritional tube into the conventional radiotherapy and paclitaxel chemotherapy for the treatment of cardia cancer patients with severe stenosis is an effective treatment, local control rate, toxicity can be tolerated.