Injuries in the choledocho-pancreatico-duo-denal junction are rare, and are frequently associated with other severe vascular and visceral injuries. Interventions during early operation may aggravate the condition of patients, while proper application of damage control surgery (DCS) is helpful in raising the survival rate. Therefore, for most of the patients with choledocho-pancereatico-duodenal junction injury, definite opera-tion should be performed after removal of necrotic tissues, control of infection and adequate drainage. However, DCS should be applied with caution, and the indications of DCS should be strictly followed, because reoperation will increase the chance of injury and infection after DCS.