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报告３８例原发性颅内生殖细胞肿瘤，好发于松果体区及鞍区，男性多见，平均年龄２０岁，临床主要表现为颅高压，视力受损，尿崩症等。光镜下，２７例为生殖细胞瘤，其中５例伴合体滋养层巨细胞，１２例伴肉芽肿形成；其余为畸胎瘤和混合性生殖细胞肿瘤各５例，单纯内胚窦瘤１例。电镜观察，见生殖细胞瘤之瘤细胞内富含糖原，瘤细胞间之小细胞成分为淋巴细胞。免疫组化标记，合体滋养层巨细胞及绒癌成分为ＨＣＧ阳性，内胚窦瘤为ＡＦＰ和ＣＥＡ阳性，胚胎癌及畸胎瘤之上皮成分为ＣＥＡ阳性，有助于进一步明确此类肿瘤内有无混合成分。
Reported 38 cases of primary intracranial germ cell tumors occur in the pineal region and the saddle area, more common in men, with an average age of 20 years old, the main clinical manifestations of intracranial hypertension, visual impairment, diabetes insipidus and so on. In the light microscope, 27 cases were germ cell tumors, of which 5 cases were associated with trophoblastic giant cells and 12 cases with granuloma; the others were teratoma and mixed germ cell tumors in 5 cases, simple endodermal sinus tumor in 1 case . Electron microscopy, see germ cell tumor cells rich in glycogen, the small cell components between lymphocytes of lymphocytes. Immunohistochemical markers, syncytiotrophoblastic giant cells and choriocarcinoma components of HCG positive, endodermal sinus tumor AFP and CEA positive, embryonic carcinoma and teratoma of the epithelial component is CEA positive, help to further clarify the type of tumor With or without mixed ingredients.