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本文阐述了尿中内皮素-I(ET-1)的病理生理学意义。研究资料表明ET-1系由肾小管分泌,ET-1的降解和重吸收均在肾小管,因此尿中ET-1水平应做为肾脏受损的一个重要标志。 ET-1是一种血管收缩剂,最早从猪的动脉内皮细胞中分离出来,用一种特殊的放免分析方法检测ET-1,证明人类血浆中和尿中一样也存在具有类似免疫反应特性的内皮素-I(ET-1-LI),并进一步证明肾脏上皮细胞线〔LLCPK,和MDCK〕也合成和分泌ET-LI。作者选择了9名志愿者(6男,4女,年龄38±6岁),和17名肾脏病患者(12男,5女,平均年龄44岁),作为研究对象。从每个个体取相同的资料,应用常规检查方法及特殊的放免分析方法进行检测,经过
This article describes the urodynamic endothelin-I (ET-1) pathophysiological significance. Research data show that ET-1 is secreted by the renal tubules, ET-1 degradation and reabsorption are in the renal tubules, so the level of ET-1 in urine should be used as an important indicator of kidney damage. ET-1, a vasoconstrictor, was first isolated from porcine arterial endothelial cells and ET-1 was detected by a special radioimmunoassay to demonstrate that human plasma has similar immunoreactive properties as in urine Endothelin-I (ET-1-LI) and further demonstrated that renal epithelial cell lines [LLCPK, and MDCK] also synthesize and secrete ET-LI. The authors selected nine volunteers (6 males and 4 females, 38 ± 6 years of age) and 17 patients with kidney disease (12 males and 5 females, mean age, 44 years) as study subjects. From each individual to take the same information, the application of routine inspection methods and special radioimmunoassay method for testing, after